Maimonides Medical Center and Columbia University, New York, NY, USA.
Int J Impot Res. 2010 Jan-Feb;22(1):1-8. doi: 10.1038/ijir.2009.29. Epub 2009 Aug 6.
The reliability of response to treatment is an important component of erectile dysfunction (ED) treatment. This study examined the reliability of tadalafil once daily (that is, successful attempts/total attempts) following initial successful intercourse. Data pooled from two randomized, double-blind, placebo-controlled trials of men with ED who received tadalafil 2.5 mg (N=96), tadalafil 5 mg (N=206) or placebo (N=148) once daily were analyzed to determine the first-attempt success rate and subsequent reliability of response. The first-attempt success rate (Sexual Encounter Profile question 3 (SEP3)) was significantly higher among men taking tadalafil 2.5 mg (45.7%) and 5 mg (55.2%) compared to placebo (28.5%; P<0.05 and P<0.001, respectively). Furthermore, following initial success, men taking tadalafil 5 mg had a significantly greater proportion of successful intercourse (SEP3) on subsequent attempts (85.9%, P<0.001) compared to men taking placebo (70.2%). Overall, men with ED taking tadalafil once daily experienced a high rate of reliability of efficacy.
治疗反应的可靠性是勃起功能障碍（ED）治疗的一个重要组成部分。本研究考察了每日一次服用他达拉非（即成功尝试/总尝试次数）在初始成功性交后的可靠性。对两项随机、双盲、安慰剂对照的 ED 男性患者（分别接受他达拉非 2.5mg（N=96）、他达拉非 5mg（N=206）或安慰剂（N=148）每日一次治疗）的数据进行了汇总分析，以确定首次尝试的成功率和随后的反应可靠性。与安慰剂（28.5%）相比，服用他达拉非 2.5mg（45.7%）和 5mg（55.2%）的男性首次尝试成功的比例显著更高（P<0.05 和 P<0.001）。此外，在首次成功后，服用他达拉非 5mg 的男性在随后的尝试中（SEP3）有更高比例的成功性交（85.9%，P<0.001），而服用安慰剂的男性仅为 70.2%。总体而言，每日一次服用他达拉非的 ED 男性的疗效可靠性较高。
