抗血管内皮生长因子（VEGF）治疗后，1例斯特奇-韦伯综合征患者持续性渗出性视网膜脱离的消退情况
Resolution of persistent exudative retinal detachment in a case of Sturge-Weber syndrome with anti-VEGF administration.
作者信息
Paulus Yannis M, Jain Atul, Moshfeghi Darius M
机构信息
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
Ocul Immunol Inflamm. 2009 Jul-Aug;17(4):292-4. doi: 10.1080/09273940902989357.
PURPOSE
Report the resolution of a persistent exudative retinal detachment in a patient with Sturge-Weber syndrome following intravitreal pegaptanib injection.
DESIGN
Case report.
METHODS
A 13-year-old male with Sturge-Weber syndrome presented with a choroidal hemangioma associated with an exudative retinal detachment that failed to resolve 6 months after external beam radiation therapy.
RESULTS
A single intravitreal pegaptanib injection resulted in 50% resolution of the detachment within 1 week and complete resolution within a month. Despite anatomic success, vision remained poor.
CONCLUSIONS
VEGF likely plays a role in the pathogenesis of Sturge-Weber choroidal hemangioma-associated exudative retinal detachment and offers potential treatment.
目的
报告玻璃体内注射培加他尼后，一名患有斯特奇-韦伯综合征患者持续性渗出性视网膜脱离的消退情况。
设计
病例报告。
方法
一名13岁患有斯特奇-韦伯综合征的男性患者，出现与渗出性视网膜脱离相关的脉络膜血管瘤，在外照射放疗6个月后仍未消退。
结果
单次玻璃体内注射培加他尼后，1周内视网膜脱离消退50%，1个月内完全消退。尽管解剖学上取得成功，但视力仍较差。
结论
血管内皮生长因子（VEGF）可能在斯特奇-韦伯综合征脉络膜血管瘤相关渗出性视网膜脱离的发病机制中起作用，并提供了潜在的治疗方法。
Zotero 插件