1例斯特奇-韦伯综合征患者中与渗出性视网膜脱离相关的弥漫性脉络膜血管瘤：光动力疗法联合玻璃体内注射贝伐单抗
Diffuse choroidal hemangioma associated with exudative retinal detachment in a Sturge-Weber syndrome case: photodynamic therapy and intravitreous bevacizumab.
作者信息
Anaya-Pava Edwin J, Saenz-Bocanegra Carlos H, Flores-Trejo Alejandro, Castro-Santana Norma A
机构信息
Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad No. 71, Ophthalmology Deparment, Torreón, Coahuila, Mexico.
Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad No. 71, Ophthalmology Deparment, Torreón, Coahuila, Mexico; Fundación Oftalmológica de la Laguna, Retina Service, Torreón, Coahuila, Mexico.
出版信息
Photodiagnosis Photodyn Ther. 2015 Mar;12(1):136-9. doi: 10.1016/j.pdpdt.2014.12.002. Epub 2015 Jan 3.
We report the case of a young female patient with a diffuse choroidal hemangioma (DCH) and glaucoma as part of Sturge-Weber syndrome (SWS) and symptomatic retinal detachment that was treated successfully with photodynamic therapy (PDT) and intravitreal bevacizumab (IVB). The patient was treated with a single session of PDT, a 689-nm laser was used to deliver 50J/cm(2) with a maximum spot size of 6400μm, for 166s. IVB was administered 3 days later. The exudative retinal detachment (ERD), macular edema and visual acuity improved one week after treatment. The patient was followed for 18 months with no recurrence of ERD, and her visual acuity was preserved. PDT followed by IVB may be an effective treatment option for visual deterioration due to ERD in patients with DCHs, as are found in SWS.
我们报告了一例年轻女性患者，其患有作为斯-韦综合征（SWS）一部分的弥漫性脉络膜血管瘤（DCH）和青光眼，以及症状性视网膜脱离，该患者通过光动力疗法（PDT）和玻璃体内注射贝伐单抗（IVB）成功治愈。患者接受了单次PDT治疗，使用689纳米激光以最大光斑尺寸6400微米递送50焦耳/平方厘米，持续166秒。3天后给予IVB。治疗1周后，渗出性视网膜脱离（ERD）、黄斑水肿和视力均有所改善。对该患者进行了18个月的随访，ERD未复发，视力得以保留。对于SWS中所见的DCH患者因ERD导致的视力恶化，PDT联合IVB可能是一种有效的治疗选择。
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