Dardas Majd, Abboud Miguel, Salti Ibrahim, Sabri Alain, Shoucair Mahmoud, Saleh Monzer, Azar Sami, Rodriguez-Galindo Carlos, Muwakkit Samar
Department of Pediatric Hematology Oncology, American University of Beirut Medical Center, Beirut, Lebanon.
Pediatr Hematol Oncol. 2009 Sep;26(6):439-47. doi: 10.1080/08880010903091806.
Thyroid carcinomas are rare in childhood and adolescence. Management of this entity remains controversial. The aim of this study is to review our experience with multidisciplinary management of papillary thyroid cancer in the pediatric population at a tertiary care specialized medical center in Lebanon.
The medical records of all patients with thyroid cancer younger than 20 years who presented to our center between January 1991 and January 2006 were reviewed.
Thirteen patients with papillary thyroid carcinoma (PTC) were identified. No patient had previous exposure to ionizing radiation. The mean age at diagnosis was 14.5 years. There were 8 females; all patients presented with a cervical mass. Ten patients underwent total thyroidectomy and three subtotal thyroidectomy. Eight patients (61.5%) had regional lymph node metastases, only one of whom (7.6%) had lung metastases. All received radioactive "131I" ablation postsurgical excision. Five (38.5%) had recurrences and needed multiple surgeries and/or "131I" ablation. At a median follow-up time of 8.3 years all patients are disease free.
Pediatric thyroid cancer in Lebanon is a rare tumor that presents mainly as a primary malignancy. The main clinical presentation is a cervical mass with locoregional lymph nodes metastasis. The mainstay of therapy is total thyroidectomy with lymph node dissection when indicated and radioactive "131I" ablation. Despite recurrences the prognosis is excellent.
甲状腺癌在儿童和青少年中较为罕见。该疾病的治疗仍存在争议。本研究的目的是回顾我们在黎巴嫩一家三级医疗专科医院对儿科患者甲状腺乳头状癌进行多学科管理的经验。
回顾了1991年1月至2006年1月期间在我们中心就诊的所有年龄小于20岁的甲状腺癌患者的病历。
共确定了13例甲状腺乳头状癌（PTC）患者。所有患者既往均未接触过电离辐射。诊断时的平均年龄为14.5岁。其中女性8例；所有患者均以颈部肿块就诊。10例行甲状腺全切除术，3例行甲状腺次全切除术。8例（61.5%）有区域淋巴结转移，其中仅1例（7.6%）有肺转移。所有患者术后均接受放射性“131I”消融治疗。5例（38.5%）复发，需要多次手术和/或“131I”消融治疗。中位随访时间为8.3年时，所有患者均无疾病。
黎巴嫩的儿童甲状腺癌是一种罕见肿瘤，主要表现为原发性恶性肿瘤。主要临床表现为颈部肿块伴局部区域淋巴结转移。治疗的主要方法是在有指征时行甲状腺全切除术及淋巴结清扫术，并进行放射性“131I”消融治疗。尽管有复发，但预后良好。
