Popovic V, Micic D, Nesovic M, Howlett T, Doniach I, Kendereski A, Djordjevic P, Manojlovic D, Micic J, Besser M
Institute of Endocrinology, Diabetes Mellitus and Metabolism, Belgrade/Yugoslavia.
Exp Clin Endocrinol. 1990 Nov;96(2):143-8. doi: 10.1055/s-0029-1211003.
Cycles of excessive cortisol secretion have been reported interposed with phases of remission lasting from few days to several months. In this study we report a ten year follow up on a patient who had four episodes of hypercortisolism and Cushing's syndrome associated with hypokalemia and edema and three long lasting spontaneous remissions. This was all caused by corticotroph pituitary adenoma. She demonstrated the longest phase of remission yet recorded in this condition, 4.5 years. The precipitating factors for the recurrence in cyclical Cushing's syndrome are not well defined, but the last recurrence in our patient appeared two months after delivery. We have discussed the continuing uncertainty of the standard dynamic tests in the differential diagnosis of Cushing's syndrome.
据报道，皮质醇分泌过多的周期中穿插着持续数天至数月的缓解期。在本研究中，我们报告了对一名患者的十年随访情况，该患者有四次皮质醇增多症发作及库欣综合征，并伴有低钾血症和水肿，还有三次长期自发缓解。这一切均由促肾上腺皮质激素垂体腺瘤引起。她表现出了这种疾病迄今记录到的最长缓解期，长达4.5年。周期性库欣综合征复发的诱发因素尚不明确，但我们这位患者的最后一次复发发生在分娩后两个月。我们已讨论了标准动态试验在库欣综合征鉴别诊断中持续存在的不确定性。
