Department of Immunology, University of Yamanashi Faculty of Medicine, Yamanashi, Japan.
Eur J Immunol. 2009 Nov;39(11):3078-83. doi: 10.1002/eji.200939302.
Both thymic stromal lymphopoietin (TSLP) and IL-13 are essential cytokines for the development of allergic inflammation. However, a causal link between TSLP and IL-13 has not yet been fully elucidated. This study aimed to investigate whether IL-13 induces TSLP expression and whether the induction contributes to the development of allergic inflammation. We found that IL-13 induced TSLP expression in mouse nasal tissue specimens in a Stat6-dependent manner. In addition, intranasal challenge of mice with IL-13 induced TSLP expression in the nasal epithelium. Importantly, intranasal IL-13 challenge induced eosinophilia and goblet cell hyperplasia in the nasal mucosa in mice, which was inhibited by the blockade of TSLP activity with anti-TSLP Ab. These findings suggest that TSLP is an important mediator of IL-13-driven allergic inflammation in the nasal mucosa. Taken together with the recent findings that IL-13 is a critical downstream element for TSLP-driven allergic inflammation, TSLP may function both upstream and downstream of IL-13, thus providing an additional rationale as to why TSLP plays such a central role in the development of allergic inflammation.
胸腺基质淋巴细胞生成素 (TSLP) 和白细胞介素-13 (IL-13) 都是过敏炎症发展所必需的细胞因子。然而，TSLP 和 IL-13 之间的因果关系尚未完全阐明。本研究旨在探讨 IL-13 是否诱导 TSLP 表达，以及这种诱导是否有助于过敏炎症的发展。我们发现，IL-13 以 Stat6 依赖的方式诱导小鼠鼻组织标本中的 TSLP 表达。此外，IL-13 鼻腔内挑战诱导小鼠鼻上皮细胞中的 TSLP 表达。重要的是，IL-13 鼻腔内挑战诱导小鼠鼻黏膜嗜酸性粒细胞增多和杯状细胞增生，而 TSLP 活性的阻断可抑制抗 TSLP Ab。这些发现表明 TSLP 是鼻黏膜中 IL-13 驱动的过敏炎症的重要介质。结合最近发现 IL-13 是 TSLP 驱动的过敏炎症的关键下游因素，TSLP 可能在上游和下游都发挥作用，从而为 TSLP 在过敏炎症发展中发挥如此核心作用提供了额外的理由。
