Gouveia Joseilme F, de Oliveira Viviane M, Sátiro Caio, Campos Paulo R A
Departamento de Estatística e Informática, Universidade Federal Rural de Pernambuco, Dois Irmãos, 5217-1-900 Recife, PE, Brazil.
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jun;79(6 Pt 1):061915. doi: 10.1103/PhysRevE.79.061915. Epub 2009 Jun 11.
We have investigated the rate of substitution of advantageous mutations in populations of haploid organisms where the rate of recombination can be controlled. We have verified that in all the situations recombination speeds up adaptation through recombination of beneficial mutations from distinct lineages in a single individual, and so reducing the intensity of clonal interference. The advantage of sex for adaptation is even stronger when deleterious mutations occur since now recombination can also restore genetic background free of deleterious mutations. However, our simulation results demonstrate that evidence of clonal interference, as increased mean selective effect of fixed mutations and reduced likelihood of fixation of small-effect mutations, are also present in sexual populations. What we see is that this evidence is delayed when compared to asexual populations.
我们研究了在重组率可控制的单倍体生物种群中有利突变的替代率。我们已经证实,在所有情况下,重组通过单个个体中不同谱系的有益突变重组来加速适应,从而降低克隆干扰的强度。当有害突变发生时,有性生殖对适应的优势甚至更强,因为此时重组还可以恢复不含有害突变的遗传背景。然而,我们的模拟结果表明,在有性种群中也存在克隆干扰的证据,如固定突变的平均选择效应增加和小效应突变固定的可能性降低。我们发现,与无性种群相比,这种证据出现得较晚。