Khar A, Gupta P D, Krishnamurthi D
Centre for Cellular & Molecular Biology, Hyderabad, India.
Indian J Exp Biol. 1990 Dec;28(12):1101-6.
Properties of a transplantable rat histiocytoma which behaves like a macrophage-like cell, have been described. The AK-5 grows as ascites as well as solid subcutaneous tumor. The ascites from one animal can give between 10(8) and 10(9) cells whereas the subcutaneous tumor grows between 20 and 40 cm3 size. These cells possess various degradative enzymes, macrophage markers and glucocorticoid receptors. Beside histopathology the surface topography and ultrastructure of these cells are described.
已描述了一种可移植的大鼠组织细胞瘤的特性，该肿瘤表现得像巨噬细胞样细胞。AK-5既能以腹水形式生长，也能形成皮下实体瘤。一只动物的腹水可产生10⁸至10⁹个细胞，而皮下肿瘤的大小在20至40立方厘米之间。这些细胞具有多种降解酶、巨噬细胞标志物和糖皮质激素受体。除了组织病理学外，还描述了这些细胞的表面形貌和超微结构。
