Sobue G
Fourth Department of Internal Medicine, Aichi Medical University.
Rinsho Shinkeigaku. 1990 Dec;30(12):1358-60.
In a wide variety of peripheral neuropathies, Schwann cells are known to be involved. However, it is still obscure whether Schwann cells play a role in the pathogenesis of nerve degeneration or are only secondarily involved in many neuropathies. Since Schwann cell culture technique is introduced, a number of Schwann cell functions have been clarified, and most of these functions are now believed to be related more with the peripheral nerve regeneration rather than degeneration. When Schwann cells are released from axonal contact, they express NGF receptor on the surface and also secrete NGF. These NGF receptor expression and NGF secretion by Schwann cells also extensively occur in the nerves undergoing active degeneration, and subside again when nerve regeneration is completed. NGF is actually a potent modulator for increasing the neurite sprouts from adult rat DRG neuron in culture. Taking account of these evidences, I discussed the role of NGF-NGF receptor system in the peripheral neuropathies.
在多种周围神经病变中，已知施万细胞会参与其中。然而，施万细胞在神经退变的发病机制中是发挥作用，还是仅在许多神经病变中继发参与，仍不清楚。自从引入施万细胞培养技术以来，已经阐明了许多施万细胞的功能，并且现在认为这些功能大多与周围神经再生而非退变关系更大。当施万细胞从轴突接触中释放出来时，它们会在表面表达NGF受体，并且还会分泌NGF。施万细胞的这些NGF受体表达和NGF分泌在正在进行主动退变的神经中也广泛发生，并在神经再生完成时再次消退。NGF实际上是一种有效的调节剂，可增加培养的成年大鼠背根神经节神经元的神经突芽。考虑到这些证据，我讨论了NGF-NGF受体系统在周围神经病变中的作用。
