生长停滞特异性蛋白 6 及其酪氨酸激酶受体 Axl 的可溶性形式的血浆浓度作为大腹主动脉瘤的标志物。
Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.
机构信息
Lund University, Department of Laboratory Medicine, Clinical Chemistry, Wallenberg Laboratory, Malmö Universitary Hospital, Entrance 46, Floor 6, SE-20502 Malmö, Sweden.
出版信息
Clin Biochem. 2010 Jan;43(1-2):110-4. doi: 10.1016/j.clinbiochem.2009.07.025. Epub 2009 Aug 4.
OBJECTIVE
The tyrosine kinase receptor Axl is expressed in the vasculature and Gas6 is the ligand. The extracellular part of Axl (sAxl) can be found in circulation. The aim of this study was to determine plasma concentrations of Gas6 and sAxl in patients with abdominal aortic aneurysms (AAA) and to evaluate if Gas6 and sAxl can be used as biomarkers.
DESIGN AND METHODS
Immunoassays for sAxl and Gas6 were used to investigate plasma from AAA patients. Patients with large (n=123) or small AAA (n=122) were compared with healthy controls (n=141).
RESULTS
Gas6 correlated positively and sAxl correlated negatively with AAA size. As a consequence, the calculated Gas6/sAxl ratios correlated even better to AAA size. Forty percent of all patients with a large AAA had higher Gas6/sAxl ratio than any in the control group.
DISCUSSION
The Gas6/Axl system might be involved in AAA pathogenesis, and the Gas6/sAxl ratio may be useful as a biomarker.
目的
酪氨酸激酶受体 Axl 在脉管系统中表达，Gas6 是其配体。Axl 的细胞外部分（sAxl）可在循环中被发现。本研究旨在确定腹主动脉瘤（AAA）患者的 Gas6 和 sAxl 血浆浓度，并评估 Gas6 和 sAxl 是否可用作生物标志物。
设计与方法
使用针对 sAxl 和 Gas6 的免疫测定法来检测 AAA 患者的血浆。将大 AAA 患者（n=123）和小 AAA 患者（n=122）与健康对照组（n=141）进行比较。
结果
Gas6 与 AAA 大小呈正相关，sAxl 与 AAA 大小呈负相关。因此，计算得出的 Gas6/sAxl 比值与 AAA 大小的相关性甚至更好。40%的大 AAA 患者的 Gas6/sAxl 比值高于任何对照组。
讨论
Gas6/Axl 系统可能参与了 AAA 的发病机制，Gas6/sAxl 比值可能是一种有用的生物标志物。
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