Shevchuk V G, Pliska A I, Bidzilia V A
Fiziol Zh SSSR Im I M Sechenova. 1990 Oct;76(10):1321-4.
The effect of the polyfunctional macroheterocycles on the rhythmic and contractile activity of the rat myocardium was found to depend on their concentration. A two-phasic effect upon contractility of the papillary muscles was revealed: a short-term (up to 20 sec) positive inotropic effect followed by a stable depression. The most active drug of this class, dicyclohexano-18-crown-6, prevented the positive inotropic action of classic stimulants (catecholamines and strophantin) upon the contractile function of the heart.
发现多功能大环化合物对大鼠心肌节律性和收缩活性的影响取决于其浓度。揭示了对乳头肌收缩性的双相效应：短期（长达20秒）正性肌力作用，随后是稳定的抑制。该类中最具活性的药物二环己基-18-冠-6可阻止经典兴奋剂（儿茶酚胺和毒毛花苷）对心脏收缩功能的正性肌力作用。
