Wills Sheila J, Barrett Esther L, Barr Frances J, Bradley Kate J, Helps Chris R, Cannon Martha J, Gruffydd-Jones Timothy J
School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol, BS40 5DU, UK.
J Feline Med Surg. 2009 Dec;11(12):993-6. doi: 10.1016/j.jfms.2009.07.002. Epub 2009 Aug 5.
Polycystic kidney disease (PKD) is the most prevalent inherited genetic disease in cats with Persian and Persian-related breeds predominantly affected. Diagnosis of PKD relied on ultrasound scanning until the recent development of the PKD gene test. However, gene testing has limitations as it will only identify the autosomal dominant form of PKD and not other forms of cystic kidney disease. Ultrasound scanning also has the advantage of being able to assess the severity and progression of disease in PKD affected cats. The aim of this study was to demonstrate the repeatability of ultrasound scanning in the detection of PKD and to assess progression of the disease over time. This study demonstrated 100% repeatability of ultrasound scanning in the detection of PKD and has also demonstrated progression of disease in 75% of PKD positive cats assessed over a 1-year period.
多囊肾病（PKD）是猫中最常见的遗传性疾病，主要影响波斯猫及与波斯猫相关的品种。在PKD基因检测出现之前，PKD的诊断依赖于超声扫描。然而，基因检测存在局限性，因为它只能识别常染色体显性形式的PKD，而无法识别其他形式的囊性肾病。超声扫描还具有能够评估PKD患猫疾病严重程度和进展情况的优势。本研究的目的是证明超声扫描在检测PKD方面的可重复性，并评估疾病随时间的进展。本研究证明了超声扫描在检测PKD方面具有100%的可重复性，并且还证明了在为期1年的评估中，75%的PKD阳性猫的疾病出现了进展。
