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[宫颈癌的手术淋巴结评估]

[Surgical lymph-node evaluation in cervical cancer].

作者信息

Mathevet P

机构信息

Service de Gynécologie, Hôpital Femme-Mère-Enfant, 69677 Bron cedex, France.

出版信息

Cancer Radiother. 2009 Oct;13(6-7):499-502. doi: 10.1016/j.canrad.2009.06.008. Epub 2009 Aug 5.

Abstract

Lymph-nodal involvement is a major prognostic factor of cervical cancer. Lymph-node status is classically evaluated by lymph-node dissection. This surgical approach has mainly a prognostic interest. The morbidity related to the lymph-node dissection is not nil, so numerous imaging or surgical techniques have been recently developed in order to reduce this morbidity. Currently, even with the progress of the imaging techniques, surgical lymph-node dissection is the standard approach. For the management of early cervical cancer, surgery is usually the sole treatment. In association with a laparoscopic lymph-node dissection, the sentinel node technique is a new approach that gives interesting data: possibility of performing frozen sections on the sentinel nodes in order to improve the management, discovery in an important proportion of cases of abnormal lymphatic pathways that are a potential aetiology of recurrence, and identification of lymph-node micrometastases that seem to be an important independent prognostic factor. In the future, evaluation of only the sentinel nodes may replace the pelvic lymph-node dissection. For advanced cervical cancers, the treatment is based on chemoradiotherapy. The paraaortic lymph-node status is an important prognostic factor that helps for defining the radiotherapy fields. New imaging techniques as PET Scan, may help for the evaluation of paraaortic lymph-node status. If the PET Scan is positive at the paraaortic level, there is no need for paraaortic lymph-node dissection and radiotherapy should be performed with pelvic and abdominal fields. But the false negative rate of the PET Scan is high and laparoscopic paraaortic lymph-node dissection is required in case of negative PET Scan at the paraaortic level.

摘要

淋巴结受累是宫颈癌的主要预后因素。淋巴结状态传统上通过淋巴结清扫来评估。这种手术方法主要具有预后意义。与淋巴结清扫相关的发病率并非为零,因此最近已开发出许多成像或手术技术以降低这种发病率。目前,即使成像技术有所进步,手术淋巴结清扫仍是标准方法。对于早期宫颈癌的治疗,手术通常是唯一的治疗方式。与腹腔镜淋巴结清扫相结合,前哨淋巴结技术是一种新方法,可提供有价值的数据:能够对前哨淋巴结进行冰冻切片以改善治疗管理,在很大比例的病例中发现异常淋巴途径,这可能是复发的潜在病因,以及识别似乎是重要独立预后因素的淋巴结微转移。未来,仅评估前哨淋巴结可能会取代盆腔淋巴结清扫。对于晚期宫颈癌,治疗基于放化疗。腹主动脉旁淋巴结状态是有助于确定放疗范围的重要预后因素。新的成像技术如正电子发射断层扫描(PET)扫描,可能有助于评估腹主动脉旁淋巴结状态。如果PET扫描显示腹主动脉旁区域为阳性,则无需进行腹主动脉旁淋巴结清扫,应进行盆腔和腹部区域的放疗。但PET扫描的假阴性率较高,若腹主动脉旁PET扫描为阴性,则需要进行腹腔镜腹主动脉旁淋巴结清扫。

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