Sewell R L
Br J Haematol. 1977 Aug;36(4):545-51. doi: 10.1111/j.1365-2141.1977.tb00995.x.
Lymphopenia and monocytosis were found in one third of untreated myeloma patients but there was no correlation between the two. Half of the patients studied had an increase in medium basophilic lymphoid cells, and eight had a raised PAS score. Lymphocytes from the majority of untreated myeloma patients failed to respond to antigenic stimulation in vitro compared with age matched controls. Three patients were immunized but showed no increase in immunoblasts or rise in antibody titre. The findings strongly suggest that abnormal lymphocytes are present in the blood in myeloma. The failure of lymphocytes to respond to antigen provides an explanation for the lack of normal plasma cells and depressed antibody responses in myeloma.
在三分之一未经治疗的骨髓瘤患者中发现淋巴细胞减少和单核细胞增多，但两者之间无相关性。所研究的患者中有一半的中等嗜碱性淋巴细胞增多，8名患者的PAS评分升高。与年龄匹配的对照组相比，大多数未经治疗的骨髓瘤患者的淋巴细胞在体外对抗原刺激无反应。3名患者接受了免疫接种，但未显示免疫母细胞增加或抗体滴度升高。这些发现有力地表明骨髓瘤患者血液中存在异常淋巴细胞。淋巴细胞对抗原无反应为骨髓瘤中缺乏正常浆细胞和抗体反应降低提供了解释。
