端粒酶抑制剂dictyodendrin B的合成方法：吡咯并[2,3-c]咔唑核心的合成。
Synthetic approach to telomerase inhibitor dictyodendrin B: synthesis of the pyrrolo[2,3-c]carbazole core.
作者信息
Hirao Shotaro, Sugiyama Yumiko, Iwao Masatomo, Ishibashi Fumito
机构信息
Graduate School of Science and Technology, Nagasaki University, Japan.
出版信息
Biosci Biotechnol Biochem. 2009 Aug;73(8):1764-72. doi: 10.1271/bbb.90111. Epub 2009 Aug 7.
PMID:19661693
Abstract
The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of 3-aryl-1-(2-arylethyl)-4-hydroxy-2,5-bismethoxycarbonylpyrrole triflate with 7-alkoxyindole-3-boronate as the key step.
摘要
端粒酶抑制剂dictyodendrin B的核心结构通过以3-芳基-1-(2-芳基乙基)-4-羟基-2,5-双甲氧基羰基吡咯三氟甲磺酸盐与7-烷氧基吲哚-3-硼酸酯的钯催化交叉偶联反应为关键步骤来合成。
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