钯催化的β-酮酯对映选择性α-羟基化反应
Palladium-catalysed enantioselective alpha-hydroxylation of beta-ketoesters.
作者信息
Smith Alexander M R, Billen Denis, Hii King Kuok Mimi
机构信息
Department of Chemistry, Imperial College London, South Kensington, London, UK.
出版信息
Chem Commun (Camb). 2009 Jul 14(26):3925-7. doi: 10.1039/b907151b. Epub 2009 May 22.
DOI:10.1039/b907151b
PMID:19662254
Abstract
Highly enantioselective alpha-hydroxylation of cyclic and acyclic 1,3-ketoesters can be achieved with up to 98% ee using a dicationic palladium(ii) catalyst and dimethyldioxirane as oxidant.
摘要
使用双阳离子钯（II）催化剂和二甲基二氧杂环丙烷作为氧化剂，可实现环状和非环状1,3 - 酮酯的高度对映选择性α-羟基化，对映体过量率高达98%。
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