Lee Jeong Won, Kang Keon Wook, Paeng Jin Chul, Lee Sang Mi, Jang Su Jin, Chung June-Key, Lee Myung Chul, Lee Dong Soo
Department of Nuclear Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul 110-744, Korea.
Ann Nucl Med. 2009 Sep;23(7):685-91. doi: 10.1007/s12149-009-0291-z. Epub 2009 Aug 7.
This study was performed to evaluate the clinical value of (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) for cancer screening in Korean asymptomatic people.
Between February 2004 and December 2006, 1,587 asymptomatic individuals underwent FDG PET/CT as part of a cancer screening program with some other diagnostic tests at the healthcare center of our hospital. After excluding patients with a history of malignant tumor, 1,336 subjects were enrolled. All PET/CT images were visually analyzed. In subjects showing positive findings for PET/CT or other screening tests, further diagnostic tests and pathological confirmation were performed.
Of the 1,336 subjects, malignant tumors were found in 16 participants (1.2%, thyroid cancer: 9, lung cancer: 2, stomach cancer: 2, and others: 4). There were 47 cases (3.6%) of positive PET/CT findings--11 cases were true positive (thyroid cancer: 8, lung cancer: 1, renal cancer: 1, and invasive thymoma), and 36 false positive, and five cases were false negative. The overall detection rate of PET/CT was 0.8%, and the sensitivity, specificity, positive-predictive value, and negative-predictive value of PET/CT were 68.8, 97.2, 23.4, and 99.6%, respectively.
Fluorodeoxyglucose positron-emission tomography has the potential to detect various kinds of malignant tumors in cancer screening test, and the overall detection rate of PET/CT was 0.8%. FDG PET/CT can be a useful cancer screening modality with the selection of high-risk group and appropriate combination with other screening modalities.
本研究旨在评估¹⁸F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）在韩国无症状人群癌症筛查中的临床价值。
2004年2月至2006年12月期间，1587名无症状个体在我院医疗中心接受了FDG PET/CT检查，作为癌症筛查项目的一部分，并进行了一些其他诊断测试。排除有恶性肿瘤病史的患者后，纳入1336名受试者。所有PET/CT图像均进行了视觉分析。对PET/CT或其他筛查测试显示阳性结果的受试者，进行了进一步的诊断测试和病理确认。
在1336名受试者中，16名参与者（1.2%）发现了恶性肿瘤（甲状腺癌：9例，肺癌：2例，胃癌：2例，其他：4例）。PET/CT检查结果阳性的有47例（3.6%）——11例为真阳性（甲状腺癌：8例，肺癌：1例，肾癌：1例，侵袭性胸腺瘤），36例为假阳性，5例为假阴性。PET/CT的总体检出率为0.8%，其敏感性、特异性、阳性预测值和阴性预测值分别为68.8%、97.2%、23.4%和99.6%。
氟脱氧葡萄糖正电子发射断层扫描在癌症筛查测试中具有检测各种恶性肿瘤的潜力，PET/CT的总体检出率为0.8%。通过选择高危人群并与其他筛查方式适当联合，FDG PET/CT可以成为一种有用的癌症筛查方式。
