尼日利亚阿南布拉州肠道病毒广泛感染的血清流行病学证据。
Seroepidemiological evidence of widespread enteroviral infection in Anambra State, Nigeria.
作者信息
Iroegbu C U
机构信息
Department of Microbiology, University of Nigeria, Nsukka, Anambra State.
出版信息
Arch Roum Pathol Exp Microbiol. 1990 Jan-Mar;49(1):63-9.
Serum samples from 339 apparently healthy subjects, 298 adult blood donors and 41 infants aged 21 months and below, were screened for neutralising activity against poliovirus 1 and Coxsackieviruses A7 and B4. Among the adult serum samples 85% showed high activity (greater than or equal to 320) against poliovirus 1 while frequencies of similar activities were 65% and 64% for Coxsackieviruses A7 and B4 respectively. About 60% showed multiple activity against all three viruses; 15% against both Coxsackieviruses A7 and B4, and less than 5% for Coxsackievirus A7 and poliovirus 1, and Coxsackievirus B4 and poliovirus 1, respectively. Similar activities were detected in the sera of the infants. These show that enterovirus infections are endemic, multiple infections being the rule.
对339名表面健康的受试者、298名成年献血者以及41名21个月及以下的婴儿的血清样本进行了检测，以筛查针对脊髓灰质炎病毒1型以及柯萨奇病毒A7和B4的中和活性。在成年血清样本中，85%对脊髓灰质炎病毒1型表现出高活性（大于或等于320），而对柯萨奇病毒A7和B4表现出类似活性的频率分别为65%和64%。约60%对所有三种病毒表现出多重活性；15%对柯萨奇病毒A7和B4均有活性，而对柯萨奇病毒A7和脊髓灰质炎病毒1型、柯萨奇病毒B4和脊髓灰质炎病毒1型分别有活性的比例均低于5%。在婴儿血清中也检测到了类似的活性。这些结果表明肠道病毒感染呈地方性流行，多重感染为常见情况。
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