急性和慢性麻痹综合征患儿的肠道病毒特异性IgM反应。
Enterovirus specific IgM responses in children with acute and chronic paralytic syndrome.
作者信息
Tuteja U, Pandya G, Bharagava R, Agarwal D, Jana A M
机构信息
Department of Microbiology, Defence Research and Development Establishment, Gwalior, India.
出版信息
J Trop Med Hyg. 1995 Dec;98(6):367-72.
Enterovirus specific IgM responses in 51 children aged 0-7 years with acute, clinically diagnosed paralytic syndrome and 8 children with chronic paralysis were detected by IgM antibody capture enzyme immunoassay. Twenty-nine out of 51 (56.86%) acute phase sera were positive for enterovirus (Polio, CVB3 and CVA7) IgM antibodies, in 21 of whom poliovirus antibodies were found in close association with CVB3 and CVA7. On the other hand, preponderance of CVA7 specific IgM was detected in 6 out of 8 sera samples of chronically paralytic children.
采用IgM抗体捕获酶免疫测定法检测了51名0至7岁临床诊断为急性麻痹综合征的儿童和8名慢性麻痹儿童的肠道病毒特异性IgM反应。51份急性期血清中有29份（56.86%）肠道病毒（脊髓灰质炎病毒、柯萨奇病毒B3型和肠道病毒A71型）IgM抗体呈阳性，其中21份中发现脊髓灰质炎病毒抗体与柯萨奇病毒B3型和肠道病毒A71型密切相关。另一方面，在8份慢性麻痹儿童的血清样本中，有6份检测到肠道病毒A71型特异性IgM占优势。
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