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大型假体与保留髁间的节段性同种异体骨移植治疗股骨远端肉瘤

Megaprosthesis versus Condyle-sparing intercalary allograft: distal femoral sarcoma.

作者信息

Zimel Melissa N, Cizik Amy M, Rapp Timothy B, Weisstein Jason S, Conrad Ernest U

机构信息

William Beaumont Hospital, Royal Oak, MI, USA.

出版信息

Clin Orthop Relat Res. 2009 Nov;467(11):2813-24. doi: 10.1007/s11999-009-1024-2. Epub 2009 Aug 7.

Abstract

UNLABELLED

Although functionally appealing in preserving the native knee, the condyle-sparing intercalary allograft of the distal femur may be associated with a higher risk of tumor recurrence and endoprosthetic replacement for malignant distal femoral bone tumors. We therefore compared the risk of local tumor recurrence between patients in these two types of reconstruction groups. We retrospectively reviewed 85 patients (mean age, 22 years; range, 4-82 years), 38 (45%) of whom had a condyle-sparing allograft and 47 (55%) of whom had endoprostheses. The minimum followup for both groups was 2 years (mean, 7 years; range, 2-19 years). Local recurrences occurred in 11% (five of 47) of the patients having implants versus 18% (seven of 38) of the patients having allografts. Using time to local recurrence as an end point, the Kaplan-Meier survivorship of the implant group was similar to that of the condyle-sparing allograft group at 2, 5, and 10 years (93% versus 87% at 2 years, 87% versus 81% at 5 years, and 87% versus 81% at 10 years, respectively). The condyle-sparing allograft procedure offers the potential advantage of retaining the native knee in a young patient population while incurring no greater risk of local recurrence as those offered the endoprosthetic procedure.

LEVEL OF EVIDENCE

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

摘要

未标注

尽管保留股骨髁的异体骨间置移植在保留天然膝关节功能方面具有吸引力,但对于股骨远端恶性骨肿瘤,其可能与肿瘤复发风险较高以及需要进行假体置换有关。因此,我们比较了这两种重建方式组患者局部肿瘤复发的风险。我们回顾性分析了85例患者(平均年龄22岁;范围4 - 82岁),其中38例(45%)接受了保留股骨髁的异体骨移植,47例(55%)接受了假体置换。两组的最短随访时间均为2年(平均7年;范围2 - 19年)。接受假体置换的患者中有11%(47例中的5例)发生局部复发,而接受异体骨移植的患者中有18%(38例中的7例)发生局部复发。以局部复发时间作为终点,在2年、5年和10年时,假体组的Kaplan - Meier生存率与保留股骨髁异体骨移植组相似(分别为93%对87%、87%对81%、87%对81%)。保留股骨髁的异体骨移植手术在年轻患者群体中具有保留天然膝关节的潜在优势,且局部复发风险并不高于假体置换手术。

证据水平

IV级,治疗性研究。有关证据水平的完整描述,请参阅作者指南。

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