Mankin Henry J
Ortopaedic Sevice, Massachussetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Chir Organi Mov. 2003 Apr-Jun;88(2):101-13.
Over the past 30 years the author and his colleagues have performed almost 1100 non-pelvic massive cadaveric allografts mostly in the treatment of malignant tumors of bone. The overall results show that 77% of the devices are still functional and competent. The best results were the intercalary grafts (86%) while the poorest were the allograft arthrodeses (61% successful). The complications of fracture and non-union are the principal problems reducing the success rate to 48% and 71% respectively. Primary infection was a major issue but occurred in less than 8% of the cases and reduced the success rate to 72%. Secondary infection following operative procedures to repair fracture or graft non-union occurred in 53 cases and reduced the success rate to less then 30%. No patients died of infection.
在过去30年里，作者及其同事进行了近1100例非骨盆大型尸体同种异体移植手术，主要用于治疗骨恶性肿瘤。总体结果显示，77%的移植器官仍功能良好。效果最佳的是节段性移植（86%），而最差的是同种异体骨融合术（成功率为61%）。骨折和骨不连并发症是主要问题，分别将成功率降至48%和71%。原发性感染是一个主要问题，但发生率不到8%，使成功率降至72%。修复骨折或移植骨不连的手术后发生的继发性感染有53例，使成功率降至不到30%。没有患者死于感染。
