Kida Satoshi, Fukushima Hotaka, Mamiya Nori
Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, 156-8502 Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 2009 Jun;29(3):125-33.
Reconsolidation and extinction of fear memories are induced by re-exposure to the conditioned stimulus (CS) but they appear to be opposite processes; as the fear memory is maintained or inhibited through reconsolidation and extinction, respectively. More importantly, reconsolidation and extinction are thought to be potential targets for the treatment of Post Traumatic Stress Disorder (PTSD). From this view, it is important to understand mechanisms by which reactivated fear memories are reconsolidated or extinguished. Here, we review processes for fear memory regulation including consolidation, reconsolidation and extinction, and discuss implications of fear memory regulation with PTSD.
恐惧记忆的重新巩固和消退是由再次暴露于条件刺激（CS）所引发的，但它们似乎是相反的过程；恐惧记忆分别通过重新巩固和消退得以维持或被抑制。更重要的是，重新巩固和消退被认为是治疗创伤后应激障碍（PTSD）的潜在靶点。从这一观点来看，了解重新激活的恐惧记忆得以重新巩固或消退的机制至关重要。在此，我们回顾恐惧记忆调节的过程，包括巩固、重新巩固和消退，并讨论恐惧记忆调节与创伤后应激障碍的关联。
