Department of Pharmaceutics and Drug Control, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Drug Dev Ind Pharm. 2010 Mar;36(3):292-301. doi: 10.1080/03639040903140589.
To study the dissolution behavior, the release mechanism and the stability of nanodispersion system of aglycones with PVP.
The nanodispersion system of polyvinylpyrrolidone (PVP)/naringenin-hesperetin was prepared using the solvent evaporation method. The chemical stability (compatibility) of naringenin and hesperetin in the prepared dispersions was studied under accelerated conditions for 3 months. The evaluation of physical stability was performed by X-ray diffraction analysis (XRD) and by comparing the dissolution profile before and after storage at high temperature and moisture (40 masculineC, RH 75%).
The dissolution rate of naringenin and hesperetin released was dramatically increased in the nanodispersion system of PVP/naringenin-hesperetin (80/20, w/w). The release mechanism of both flavanone aglycones was better described by the diffusion model (Higuchi model). Also it was found that the rate-limiting step that controlled the release of naringenin and hesperetin in the nanodispersion system was dissolution of the carrier (PVP).
During accelerated degradation analysis, for 3 months at high temperature and moisture, PVP nanodispersion system showed enhanced chemical compatibility and physical stability. The physical evaluation (obtained from XRD analysis) of PVP/naringenin-hesperetin (80/20, w/w) in the selected storage conditions did not show any crystallization of flavanone aglycones in the PVP nanodispersion system or any change in their release profile.
研究与 PVP 形成的苷元纳米分散体的溶出行为、释放机制和稳定性。
采用溶剂蒸发法制备聚维酮（PVP）/柚皮素-橙皮素纳米分散体。在加速条件下研究 3 个月，研究制备分散体中柚皮素和橙皮素的化学稳定性（相容性）。通过 X 射线衍射分析（XRD）和比较高温高湿（40°C，RH75%）储存前后的溶出曲线来评估物理稳定性。
PVP/柚皮素-橙皮素（80/20，w/w）纳米分散体显著提高了柚皮素和橙皮素的溶出速率。两种黄烷酮苷元的释放机制均较好地用扩散模型（Higuchi 模型）描述。还发现，控制纳米分散体中柚皮素和橙皮素释放的速度限制步骤是载体（PVP）的溶解。
在高温高湿加速降解分析中，3 个月后，PVP 纳米分散体显示出增强的化学相容性和物理稳定性。在所选储存条件下，对 PVP/柚皮素-橙皮素（80/20，w/w）的物理评价（XRD 分析获得）并未显示出 PVP 纳米分散体中黄烷酮苷元结晶或其释放曲线有任何变化。
