Tufano Maria, Nicastro Emanuele, Giliberti Paolo, Vegnente Angela, Raimondi Francesco, Iorio Raffaele
Department of Pediatrics, University of Naples Federico II, Naples, Italy.
Acta Paediatr. 2009 Nov;98(11):1756-61. doi: 10.1111/j.1651-2227.2009.01464.x. Epub 2009 Aug 6.
Prevalence, aetiology, management and outcome of cholestasis were evaluated in infants admitted to neonatal intensive care unit (NICU).
Medical records of all infants admitted to two Italian level III NICUs from January 2005 to August 2007 were retrospectively reviewed. The role of ursodeoxycholic acid (UDCA) therapy was also investigated.
Twenty-seven of 1289 enrolled infants developed cholestasis. In 25 infants, cholestasis had a multifactorial basis, while in two, no aetiology was found. UDCA did not significantly affect clinical and biochemical course of cholestasis. During a period of 12 months, eight cholestatic infants died, one underwent liver transplantation and 18 fully recovered.
Infants admitted in NICU have a rate of cholestasis higher than that reported in the general population of live births; in most cases, cholestasis is associated to multiple risk factors and shows a favourable outcome. UDCA does not seem to affect clinical course of cholestasis in this setting.
对入住新生儿重症监护病房（NICU）的婴儿胆汁淤积症的患病率、病因、治疗及预后进行评估。
回顾性分析2005年1月至2007年8月入住两家意大利三级NICU的所有婴儿的病历。同时研究了熊去氧胆酸（UDCA）治疗的作用。
1289名入选婴儿中有27名发生胆汁淤积症。25名婴儿的胆汁淤积症有多种因素，另外两名未发现病因。UDCA对胆汁淤积症的临床和生化病程无显著影响。在12个月期间，8名胆汁淤积症婴儿死亡，1名接受肝移植，18名完全康复。
入住NICU的婴儿胆汁淤积症发生率高于活产婴儿总体报告的发生率；在大多数情况下，胆汁淤积症与多种危险因素相关，且预后良好。在此情况下，UDCA似乎不影响胆汁淤积症的临床病程。
