Wing J B, Jack D L, Lee M E, Pacey A A, Kinghorn G R, Read R C
Academic Unit of Infection and Immunity, University of Sheffield Medical School, Sheffield S10 2RX, UK.
Clin Exp Immunol. 2009 Sep;157(3):408-14. doi: 10.1111/j.1365-2249.2009.03984.x.
Mannose-binding lectin (MBL) is an innate immune molecule present in blood and some mucosal tissues, which can influence microbial attachment and inflammatory responses of host cells during infection. In this study MBL was found to be present at a low concentration in semen samples in the range 1.2-24.9 ng/ml. Co-incubation of bacteria with semen resulted in the binding of MBL to the bacterial surface. Neisseria gonorrhoeae is a common cause of genitourinary infection. MBL bound to N. gonorrhoeae with strain-to-strain variation in the intensity of binding and nature of the bacterial receptor. Pretreatment with MBL concentrations similar to those found in human serum modulated the adhesion of N. gonorrhoeae strain FA1090 but not strain MS11 to epithelial cells. This effect was dose-dependent. This work demonstrates that MBL is present in human semen and modifies cellular responses to N. gonorrhoeae in a concentration-dependent manner.
甘露糖结合凝集素（MBL）是一种存在于血液和某些黏膜组织中的天然免疫分子，在感染过程中它可影响微生物的附着以及宿主细胞的炎症反应。在本研究中，发现精液样本中MBL的浓度较低，范围为1.2 - 24.9 ng/ml。细菌与精液共同孵育导致MBL与细菌表面结合。淋病奈瑟菌是泌尿生殖道感染的常见病因。MBL与淋病奈瑟菌结合，不同菌株之间结合强度和细菌受体性质存在差异。用与人血清中相似浓度的MBL预处理可调节淋病奈瑟菌FA1090菌株对上皮细胞的黏附，但对MS11菌株无此作用。这种效应呈剂量依赖性。这项研究表明，MBL存在于人类精液中，并以浓度依赖的方式改变细胞对淋病奈瑟菌的反应。
