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如何构建核仁小体。

How to build a paraspeckle.

机构信息

Functional RNomics Team, Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koutou, Tokyo 135-0064, Japan.

出版信息

Genome Biol. 2009;10(7):227. doi: 10.1186/gb-2009-10-7-227. Epub 2009 Jul 16.

DOI:10.1186/gb-2009-10-7-227
PMID:19664169
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2728519/
Abstract

Noncoding RNAs have recently been identified as essential components of the nuclear suborganelles called paraspeckles. This finding will facilitate our understanding of the molecular dynamics and physiological role of these enigmatic macromolecular structures.

摘要

非编码 RNA 最近被鉴定为核亚细胞器——核小体仁（paraspeckles）的重要组成部分。这一发现将有助于我们理解这些神秘的大分子结构的分子动力学和生理作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aca/2728519/7027daeb2c5b/gb-2009-10-7-227-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aca/2728519/8c498d817de3/gb-2009-10-7-227-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aca/2728519/7027daeb2c5b/gb-2009-10-7-227-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aca/2728519/8c498d817de3/gb-2009-10-7-227-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aca/2728519/7027daeb2c5b/gb-2009-10-7-227-2.jpg

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2
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本文引用的文献

1
An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.一种核非编码RNA的结构作用：NEAT1 RNA对旁斑结构至关重要。
Mol Cell. 2009 Mar 27;33(6):717-26. doi: 10.1016/j.molcel.2009.01.026. Epub 2009 Feb 12.
2
MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles.MENε/β非编码RNA对于核旁斑的结构完整性至关重要。
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2525-30. doi: 10.1073/pnas.0807899106. Epub 2009 Feb 2.
3
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.
RNA. 2021 Dec;27(12):1427-1440. doi: 10.1261/rna.078971.121. Epub 2021 Sep 15.
4
Direct RNA-RNA interaction between Neat1 and RNA targets, as a mechanism for RNAs paraspeckle retention.Neat1 与 RNA 靶标之间的直接 RNA-RNA 相互作用，作为 RNA 进入核斑点的保留机制。
RNA Biol. 2021 Nov;18(11):2016-2027. doi: 10.1080/15476286.2021.1889253. Epub 2021 Mar 15.
5
Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies.核仁隔离：将核仁重塑为淀粉样小体。
Front Genet. 2019 Nov 21;10:1179. doi: 10.3389/fgene.2019.01179. eCollection 2019.
6
CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.CARM1 和核旁斑点调节小鼠胚胎植入前发育。
Cell. 2018 Dec 13;175(7):1902-1916.e13. doi: 10.1016/j.cell.2018.11.027.
7
NEAT1_2-SFPQ axis mediates cisplatin resistance in liver cancer cells in vitro.NEAT1_2-SFPQ轴在体外介导肝癌细胞对顺铂的耐药性。
Onco Targets Ther. 2018 Sep 11;11:5695-5702. doi: 10.2147/OTT.S163774. eCollection 2018.
8
The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization.乙型肝炎 delta 病毒的积累需要副核小体成分，并影响 NEAT1 水平和 PSP1 的定位。
Sci Rep. 2018 Apr 16;8(1):6031. doi: 10.1038/s41598-018-24500-1.
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Cell Cycle. 2017 Jun 18;16(12):1175-1180. doi: 10.1080/15384101.2017.1317419. Epub 2017 Apr 20.
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Paraspeckles as rhythmic nuclear mRNA anchorages responsible for circadian gene expression.作为有节奏的核 mRNA 附着点的核仁小体，负责昼夜节律基因表达。
Nucleus. 2017 May 4;8(3):249-254. doi: 10.1080/19491034.2016.1277304. Epub 2017 Jan 6.
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6
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Histochem Cell Biol. 2008 Jan;129(1):5-11. doi: 10.1007/s00418-007-0355-x. Epub 2007 Nov 10.
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