危重症患者的 B 型利钠肽水平：误导严重？
B-type natriuretic levels in critically ill patients: critically misleading?
机构信息
Department of Medicine, Baylor College of Medicine, 6620 Main Street, 11A,08, Houston, TX 77030, USA.
出版信息
Crit Care. 2009;13(4):163. doi: 10.1186/cc7938. Epub 2009 Jul 13.
Abstract
Although B-type natriuretic peptide (BNP) has been used for the diagnosis of congestive heart failure in many clinical settings, its diagnostic role in critically ill patients remains uncertain. The body of literature suggests that BNP and N-terminal pro-BNP levels are not useful for the diagnosis of systolic or diastolic heart failure in the critically ill, including in patients with brain hemorrhage, due to poor specificity. However, these cardiac peptides may have a more promising prognostic role in this patient population.
摘要
尽管 B 型利钠肽（BNP）已在许多临床环境中用于心力衰竭的诊断，但它在危重病患者中的诊断作用仍不确定。文献表明，BNP 和氨基末端脑利钠肽前体（NT-proBNP）水平对包括脑出血患者在内的危重病患者收缩性或舒张性心力衰竭的诊断没有帮助，原因是特异性较差。然而，这些心肽在该患者人群中可能具有更有前途的预后作用。
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Shock. 2009 Apr;31(4):342-7. doi: 10.1097/SHK.0b013e31818635b6.
3
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