Cavanagh D, Davis P, Cook J, Li D
AFRC Institute for Animal Health, Houghton Laboratory, Huntington, Cambridgeshire, UK.
Adv Exp Med Biol. 1990;276:369-72. doi: 10.1007/978-1-4684-5823-7_50.
IBV serotype-specific, virus neutralising (VN) antibody is induced by the S1 subunit of the spike (S) glycoprotein. A Portuguese isolate (Port/322/85) is considered to be an in vivo recombinant. VN tests showed that it belongs to the Massachussetts (Mass) serotype. Correspondingly, the sequence of S1 and S2 was extremely similar to that of older Mass isolates. However, the matrix (M) glycoprotein and upstream gene sequences were atypical of these Mass strains and more closely resembled other serotypes isolated in Europe. The recombination event had occurred within the sequence between the M and S genes (corresponding to mRNA 3) or near the 3' terminus of the S2 gene.
传染性支气管炎病毒（IBV）血清型特异性的病毒中和（VN）抗体由刺突（S）糖蛋白的S1亚基诱导产生。一株葡萄牙分离株（Port/322/85）被认为是体内重组体。VN试验表明它属于马萨诸塞州（Mass）血清型。相应地，S1和S2的序列与较老的Mass分离株的序列极为相似。然而，基质（M）糖蛋白和上游基因序列对于这些Mass毒株来说是非典型的，并且与在欧洲分离的其他血清型更为相似。重组事件发生在M基因和S基因之间的序列（对应于mRNA 3）内或S2基因的3'末端附近。
