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18F-氟脱氧葡萄糖正电子发射断层显像/计算机断层扫描（FDG-PET/CT）检测到的甲状腺偶发病变：甲状腺癌的患病率和风险

Incidental thyroid lesions detected by FDG-PET/CT: prevalence and risk of thyroid cancer.

作者信息

Bae Ja Seong, Chae Byung Joo, Park Woo Chan, Kim Jeong Soo, Kim Sung Hoon, Jung Sang Seol, Song Byung Joo

机构信息

Department of Surgery, The Catholic University of Korea, Seoul, Korea.

出版信息

World J Surg Oncol. 2009 Aug 10;7:63. doi: 10.1186/1477-7819-7-63.

DOI:10.1186/1477-7819-7-63
PMID:19664272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2732624/
Abstract

BACKGROUND

Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer.

METHODS

FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively.

RESULTS

Two hundred eighty five patients (8.4%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2% (22/99) and the cancer risks associated with focal and diffuse FDG uptake were 30.9% and 6.4%. There was a significant difference in the SUVmax between the benign and malignant nodules (3.35 +/- 1.69 vs. 6.64 +/- 4.12; P < 0.001). There was a significant correlation between the SUVmax and the size of the cancer.

CONCLUSION

The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.

摘要

背景

在接受氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）的患者中，经常会偶然发现甲状腺病变。本研究的目的是调查接受FDG-PET/CT检查的患者中偶然发现甲状腺病变的患病率，并确定甲状腺癌的风险。

方法

2003年11月至2005年12月期间，对3379例患者进行了FDG-PET/CT检查，以评估疑似或已知癌症或进行癌症筛查，这些患者均无甲状腺癌病史。回顾性分析与FDG-PET/CT检查结果相关的病历，包括最大标准摄取值（SUVmax）和FDG摄取模式、超声检查结果、细针穿刺活检（FNA）以及手术获得的组织病理学结果。

结果

285例患者（8.4%）在FDG-PET/CT检查中被发现有FDG摄取。99例有局灶性或弥漫性FDG摄取的患者接受了进一步评估。FDG-PET/CT偶然发现的甲状腺病变的癌症风险为23.2%（22/99），与局灶性和弥漫性FDG摄取相关的癌症风险分别为30.9%和6.4%。良性和恶性结节之间的SUVmax存在显著差异（3.35±1.69 vs. 6.64±4.12；P<0.001）。SUVmax与癌症大小之间存在显著相关性。

结论

本研究结果表明，FDG-PET/CT偶然发现的甲状腺病变，尤其是局灶性FDG摄取和高SUV值，具有较高的甲状腺恶性风险。在这些病例中需要进一步的诊断检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/01c46aaa69d1/1477-7819-7-63-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/856641a864d2/1477-7819-7-63-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/8ccc2d958fe5/1477-7819-7-63-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/4f5be1c68f5c/1477-7819-7-63-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/867d00f2cda3/1477-7819-7-63-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/01c46aaa69d1/1477-7819-7-63-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/856641a864d2/1477-7819-7-63-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/8ccc2d958fe5/1477-7819-7-63-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/4f5be1c68f5c/1477-7819-7-63-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/867d00f2cda3/1477-7819-7-63-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3e4/2732624/01c46aaa69d1/1477-7819-7-63-5.jpg

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本文引用的文献

1
Role of thyroid ultrasound in the diagnostic evaluation of thyroid nodules.甲状腺超声在甲状腺结节诊断评估中的作用。
Best Pract Res Clin Endocrinol Metab. 2008 Dec;22(6):913-28. doi: 10.1016/j.beem.2008.09.016.
2
Evaluation and imaging of a thyroid nodule.甲状腺结节的评估与成像
Surg Oncol Clin N Am. 2008 Jan;17(1):37-56, vii-viii. doi: 10.1016/j.soc.2007.10.006.
3
FDG-PET detected thyroid incidentalomas: need for further investigation?氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）检测到的甲状腺偶发瘤：是否需要进一步检查？
FDG uptake reflects an immune-enriched subtype of thyroid cancer: Clinical implications of imaging-based molecular characterization.
氟代脱氧葡萄糖摄取反映了富含免疫的甲状腺癌亚型：基于影像的分子特征分析的临床意义。
Cancer Med. 2023 Aug;12(16):17068-17077. doi: 10.1002/cam4.6350. Epub 2023 Jul 19.
4
Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19.急性 COVID-19 康复期 F-18 FDG 全身 PET 与功能性脑 MRI 的异常模式
Nucl Med Mol Imaging. 2022 Feb;56(1):29-41. doi: 10.1007/s13139-021-00730-6. Epub 2022 Jan 15.
5
Prevalence of incidental thyroid malignancy on routine F-fluorodeoxyglucose PET-CT in a large teaching hospital.一家大型教学医院中，常规氟脱氧葡萄糖PET-CT检查时偶然发现的甲状腺恶性肿瘤的患病率。
Eur J Hybrid Imaging. 2020 Nov 16;4(1):21. doi: 10.1186/s41824-020-00089-5.
6
Thyroid incidentalomas with increased focal F-FDG uptake in F-FDG PET/CT of a patient with multiple primary cancers.在一名患有多种原发性癌症患者的F-FDG PET/CT检查中出现局灶性F-FDG摄取增加的甲状腺偶发瘤。
Endocrine. 2021 Aug;73(2):491-492. doi: 10.1007/s12020-021-02661-w. Epub 2021 Apr 27.
7
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8
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9
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10
Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter.因良性结节性甲状腺肿接受甲状腺切除术的患者术前未诊断出的乳头状甲状腺癌。
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Ann Surg Oncol. 2007 Jan;14(1):239-47. doi: 10.1245/s10434-006-9181-y. Epub 2006 Oct 6.
4
Integrated 18F-FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast-enhanced CT.18F-FDG PET/CT 一体化成像用于甲状腺乳头状癌患者颈部淋巴结水平的初始评估：与超声及增强CT的比较
Clin Endocrinol (Oxf). 2006 Sep;65(3):402-7. doi: 10.1111/j.1365-2265.2006.02612.x.
5
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6
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Am Surg. 2006 Mar;72(3):272-5.
7
Preoperative evaluation of thyroid nodules with 18FDG-PET/CT.甲状腺结节的18FDG-PET/CT术前评估
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8
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9
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10
The thyroid incidentaloma: an increasingly frequent consequence of radiologic imaging.甲状腺偶发瘤：放射影像学检查日益常见的结果。
Semin Ultrasound CT MR. 2005 Feb;26(1):37-46. doi: 10.1053/j.sult.2004.10.004.