Ma Jin-an, Qiu Zhen-hua, Pei Hai-ping
Department of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Aug;25(8):714-5.
To investigate the expression of chemokine receptor CCR1 in the human colorectal carcinoma and its correlation with metastasis of lymph nodes.
By immunohistochemistry, the expression of CCR1 was studied in the colorectal carcinoma of 83 cases and 15 normal cases as control subjects.
The positive expression rates of CCR1 in the colorectal carcinoma tissues with deep invasion, poor differentiation, metastasis and higher Dukes' stage were significantly higher than those with superficial invasion (P<0.05), well or moderate differentiation (P<0.05), non-metastasis (P<0.01) and lower Dukes' stage (P<0.05). The LMVD was higher in colorectal carcinoma tissues with positive CCR1 staining than those with negative CCR1 staining (P<0.01). But the MVD had no significantly difference in positive CCR1 staining tissues and negative CCR1 staining tissues.
The expression of chemokine receptor CCR1 is higher in colorectal carcinoma than normal tissues, and it may correlate with lymph node metastasis.
