Cohen Solal Alain, Tournoux François, Beauvais Florence, Tartiere Jean-Michel
Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Denis Diderot, INSERM U942, Paris, France.
Therapie. 2009 Mar-Apr;64(2):101-9. doi: 10.2515/therapie/2009012. Epub 2009 Aug 11.
The concept of heart failure with preserved left ventricular ejection fraction has replaced that of diastolic heart failure. It is today the most frequent presentation of heart failure because of the progressive aging of the population. Its prognosis appears to be similar to that of heart failure with reduced systolic function. B type natriuretic peptide dosing as well as doppler-echocardiography are useful for the diagnosis. Today, no treatment has revealed effective but clinical trials have been scarce. Renin-angiotensin system antagonists have promising properties but haven't shown efficacy. This article reviews the epidemiologic, diagnostic, pathophysiologic and therapeutic aspects of the disease.
射血分数保留的心力衰竭这一概念已取代舒张性心力衰竭。由于人口的逐渐老龄化,它如今是心力衰竭最常见的表现形式。其预后似乎与收缩功能降低的心力衰竭相似。B型利钠肽检测以及多普勒超声心动图对诊断很有用。目前,尚无治疗方法显示有效,但临床试验很少。肾素 - 血管紧张素系统拮抗剂具有有前景的特性,但尚未显示出疗效。本文综述了该疾病的流行病学、诊断、病理生理学和治疗方面。