Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
J Biosci Bioeng. 2009 Sep;108(3):244-7. doi: 10.1016/j.jbiosc.2009.04.004.
A multilayered keratinocyte sheet overexpressing human beta defensin-3 (HBD-3) gene was prepared by the magnetic force-based tissue engineering technique. The cell sheet demonstrated significant antimicrobial activity, indicating that the therapeutic introduction of HBD-3 gene into cell sheets may provide a new gene therapy strategy for infectious diseases.
通过基于磁力的组织工程技术制备了过表达人β防御素-3（HBD-3）基因的多层角蛋白细胞片。该细胞片表现出显著的抗菌活性，表明将 HBD-3 基因导入细胞片中的治疗方法可能为传染病提供新的基因治疗策略。
