巴西中西部地区一些本土植物对埃及伊蚊的杀幼虫活性。
Larvicidal activity against Aedes aegypti of some plants native to the West-Central region of Brazil.
作者信息
Garcez Walmir S, Garcez Fernanda R, da Silva Lilliam M G E, Hamerski Lidilhone
机构信息
Departamento de Química, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil.
出版信息
Bioresour Technol. 2009 Dec;100(24):6647-50. doi: 10.1016/j.biortech.2009.06.092. Epub 2009 Aug 6.
A total of 42 ethanolic extracts from 30 different plant species, native to the Pantanal and Cerrado of the West-Central region of Brazil, have been evaluated for their larvicidal activity against Aedes aegypti larvae, the vector of dengue and dengue hemorrhagic fevers. Among the extracts tested, that obtained from the trunk bark of Ocotea velloziana was the most active. Using a bioassay-directed fractionation of this extract, the active constituent was isolated and characterized as the aporphine alkaloid (+)-dicentrine. Its structure was established on the basis of (1)H and (13)C NMR spectra, optical rotation and by comparison with an authentic sample. This is the first report on the larvicidal activity against A. aegypti of this alkaloid. Our results suggest that (+)-dicentrine may be considered as a promising natural mosquito larvicidal agent.
对来自巴西中西部地区潘塔纳尔湿地和塞拉多的30种不同植物的42种乙醇提取物进行了评估，以检测其对埃及伊蚊幼虫（登革热和登革出血热的传播媒介）的杀幼虫活性。在所测试的提取物中，从维洛齐奥柯替木树干树皮中获得的提取物活性最强。通过对该提取物进行生物测定导向的分级分离，分离出活性成分并鉴定为阿朴啡生物碱（+）-双氢荷包牡丹碱。根据¹H和¹³C NMR光谱、旋光度并与标准样品比较确定了其结构。这是关于该生物碱对埃及伊蚊杀幼虫活性的首次报道。我们的结果表明，（+）-双氢荷包牡丹碱可被视为一种有前景的天然灭蚊幼虫剂。
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