雌二醇和儿茶酚雌二醇的大分子效应与前列腺儿茶酚雌激素总浓度之间的相关性。

Correlation between the macromolecular effects of estradiol and catecholestradiols and the total prostatic catecholestrogen concentration.

作者信息

Nieuwoudt L B, van Aswegen C H, Böckmann H I, van der Merwe C A, du Plessis D J

机构信息

Wolmarans Research Laboratory, Department of Urology, University of Pretoria, Republic of South Africa.

出版信息

Clin Physiol Biochem. 1990;8(5):231-7.

PMID:1966528

Abstract

Various authors have demonstrated that estrogens stimulate both protein and DNA synthesis, as well as cell proliferation. This study was therefore undertaken to investigate the correlation between these physiological effects of estrogens and the total prostatic catecholestrogens. Either 17 beta-estradiol (5 ng), 2-hydroxyestradiol (40 ng), 4-hydroxyestradiol (17 ng), propane-1,2-diol or a saline solution was injected intraperitoneally to 22-day-old Sprague-Dawley rats daily. Regardless of the treatment, the prostate mass, the rate of DNA or protein synthesis correlates positively with the total prostatic catecholestrogen concentration. We therefore conclude that the effect of each estrogen per se should be regarded in terms of the total prostatic catecholestrogen concentration.

摘要

多位作者已证明，雌激素可刺激蛋白质和DNA合成以及细胞增殖。因此，开展本研究以探讨雌激素的这些生理效应与前列腺总儿茶酚雌激素之间的相关性。将17β-雌二醇（5纳克）、2-羟基雌二醇（40纳克）、4-羟基雌二醇（17纳克）、1,2-丙二醇或盐溶液每日腹腔注射给22日龄的斯普拉格-道利大鼠。无论采用何种处理，前列腺重量、DNA或蛋白质合成速率均与前列腺总儿茶酚雌激素浓度呈正相关。因此，我们得出结论，每种雌激素本身的效应应根据前列腺总儿茶酚雌激素浓度来考虑。