Anton Smith A, Manavalan R, Kannan K, Rajendiran N
Department of Pharmacy, Annamalai University, Annamalai Nagar 608002, Tamilnadu, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2009 Oct 1;74(2):469-77. doi: 10.1016/j.saa.2009.06.047. Epub 2009 Jul 1.
Effect of solvents and beta-cyclodextrin on the absorption and fluorescence spectra of tramadol drug has been investigated and compared with anisole. The solid inclusion complex of tramadol with beta-CD is investigated by FT-IR, (1)H NMR, scanning electron microscope (SEM), DSC and semiempirical methods. The thermodynamic parameter (DeltaG) of inclusion process is determined. A solvent study shows (i) the spectral behaviour of both tramadol and anisole molecules is similar to each other and (ii) the cyclohexanol group in tramadol is not effectively conjugated with anisole group. However, in beta-CD, due to space restriction of the CD cavity, a weak interaction is present between the above groups in tramadol. beta-Cyclodextrin studies show that tramadol forms 1:2 inclusion complex with beta-CD. A mechanism is proposed for the inclusion process.
研究了溶剂和β-环糊精对曲马多药物吸收光谱和荧光光谱的影响，并与苯甲醚进行了比较。通过傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（¹H NMR）、扫描电子显微镜（SEM）、差示扫描量热法（DSC）和半经验方法对曲马多与β-环糊精的固体包合物进行了研究。测定了包合过程的热力学参数（ΔG）。溶剂研究表明：（i）曲马多和苯甲醚分子的光谱行为彼此相似；（ii）曲马多中的环己醇基团与苯甲醚基团没有有效共轭。然而，在β-环糊精中，由于环糊精空腔的空间限制，曲马多中上述基团之间存在弱相互作用。β-环糊精研究表明，曲马多与β-环糊精形成1:2的包合物。提出了包合过程的机制。
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