Shanmugam M, Ramesh D, Nagalakshmi V, Kavitha R, Rajamohan R, Stalin T
Department of Chemistry, Muthayammal College of Arts and Science, Rasipuram, Namakkal 637408, Tamilnadu, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2008 Nov 1;71(1):125-32. doi: 10.1016/j.saa.2007.10.054. Epub 2007 Nov 29.
The inclusion complexes of beta-cyclodextrin (beta-CD) with L-tyrosine (L-TYN) were investigated by using spectrophotometers. The absorption and fluorescence enhancement occurs with beta-CD and L-TYN forms 1:1 inclusion complex. The unusual blue shift of hydroxyl ion in the beta-CD medium confirms OH groups present in the interior part of the beta-CD cavity and -COOH group present in the upper part of the beta-CD cavity. A mechanism is proposed to explain inclusion process. The inclusion interaction was examined and the thermodynamic parameters of inclusion process DeltaG, DeltaH and DeltaS were determined. The results indicated that the inclusion process was an exergonic and spontaneous process. Stable solid inclusion complexes were established and characterized by FT-IR, scanning electron microscope (SEM) methods.
采用分光光度计研究了β-环糊精（β-CD）与L-酪氨酸（L-TYN）的包合物。β-CD与L-TYN形成1:1包合物时会出现吸收和荧光增强现象。β-CD介质中羟基离子的异常蓝移证实了β-CD空腔内部存在羟基以及β-CD空腔上部存在羧基。提出了一种机制来解释包合过程。研究了包合相互作用，并测定了包合过程的热力学参数ΔG、ΔH和ΔS。结果表明，包合过程是一个放能且自发的过程。制备了稳定的固体包合物，并通过傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）方法对其进行了表征。
