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Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release.

作者信息

Hofmann Alan F, Mangelsdorf David J, Kliewer Steven A

出版信息

Clin Gastroenterol Hepatol. 2009 Nov;7(11):1151-4. doi: 10.1016/j.cgh.2009.07.026. Epub 2009 Aug 7.

DOI:10.1016/j.cgh.2009.07.026
PMID:19665580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2850200/
Abstract
摘要

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本文引用的文献

1
Bile acids: regulation of synthesis.胆汁酸：合成的调控。
J Lipid Res. 2009 Oct;50(10):1955-66. doi: 10.1194/jlr.R900010-JLR200. Epub 2009 Apr 3.
2
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.胆汁酸激活人肝细胞中的成纤维细胞生长因子19信号通路，以抑制胆固醇7α-羟化酶基因的表达。
Hepatology. 2009 Jan;49(1):297-305. doi: 10.1002/hep.22627.
3
Co-receptor requirements for fibroblast growth factor-19 signaling.成纤维细胞生长因子19信号传导的共受体需求
J Biol Chem. 2007 Oct 5;282(40):29069-72. doi: 10.1074/jbc.C700130200. Epub 2007 Aug 21.
4
Liver-specific activities of FGF19 require Klotho beta.成纤维细胞生长因子19的肝脏特异性活性需要β-klotho。
J Biol Chem. 2007 Sep 14;282(37):27277-27284. doi: 10.1074/jbc.M704244200. Epub 2007 Jul 11.
5
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.对成纤维细胞生长因子19亚家族成员依赖α-klotho的内分泌作用模式的分子见解。
Mol Cell Biol. 2007 May;27(9):3417-28. doi: 10.1128/MCB.02249-06. Epub 2007 Mar 5.
6
Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption.胆汁酸吸收不良患者分离黏膜中胆汁酸摄取正常或增加。
Eur J Gastroenterol Hepatol. 2006 Apr;18(4):397-403. doi: 10.1097/00042737-200604000-00013.
7
OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.OSTα - OSTβ：人类肠道、肾脏和胆管上皮细胞中的一种主要的基底外侧胆汁酸和类固醇转运蛋白。
Hepatology. 2005 Dec;42(6):1270-9. doi: 10.1002/hep.20961.
8
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.成纤维细胞生长因子15作为一种肠肝信号，调节胆汁酸稳态。
Cell Metab. 2005 Oct;2(4):217-25. doi: 10.1016/j.cmet.2005.09.001.
9
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.缺乏β-klotho的小鼠中胆汁酸合成的负反馈抑制受损。
J Clin Invest. 2005 Aug;115(8):2202-8. doi: 10.1172/JCI23076.
10
New treatment for bile salt malabsorption.胆汁盐吸收不良的新疗法。
Gut. 2005 Mar;54(3):441-2. doi: 10.1136/gut.2004.054486.