Kriz Nancy, Rinder Christine S, Rinder Henry M
Department of Laboratory Medicine, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT 05620, USA.
Clin Lab Med. 2009 Jun;29(2):159-74, v. doi: 10.1016/j.cll.2009.06.004.
This article briefly details the physiologic and interdependent mechanisms of vascular hemostasis, with an eye toward how the laboratory can assist in diagnosing and maintaining the balance of procoagulant and anticoagulant functions. These functions include determining characteristics of the blood vessel wall, platelet components and receptor-ligand interactions critical for hemostasis, the regulation of thrombin generation and its effects, and the complex fibrinolytic pathways that complete the coagulation cascade.
本文简要详述了血管止血的生理及相互依存机制，着眼于实验室如何协助诊断并维持促凝血和抗凝血功能的平衡。这些功能包括确定血管壁的特征、血小板成分以及对止血至关重要的受体-配体相互作用、凝血酶生成的调节及其作用，以及完成凝血级联反应的复杂纤维蛋白溶解途径。
