血管性血友病的实验室检测：迈向基于机制的分类
Laboratory testing for von Willebrand disease: toward a mechanism-based classification.
作者信息
Torres Richard, Fedoriw Yuri
机构信息
Department of Laboratory Medicine, Yale School of Medicine, 333 Cedar Street, P.O. Box 208035, New Haven, CT 06520-8035, USA.
出版信息
Clin Lab Med. 2009 Jun;29(2):193-228. doi: 10.1016/j.cll.2009.06.005.
Abstract
The heterogeneity of von Willebrand disease reflects the varied roles of von Willebrand factor in coagulation. Significant challenges remain in the detection, classification, and determination of bleeding risk in disorders related to von Willebrand factor. A clearer understanding of the specific disease mechanisms is essential to the development of improved methods for prognosis and management in this and other conditions with abnormalities of the von Willebrand factor system.
摘要
血管性血友病的异质性反映了血管性血友病因子在凝血过程中的多种作用。在与血管性血友病因子相关的疾病中，其检测、分类以及出血风险的判定仍面临重大挑战。更清晰地了解具体的疾病机制对于开发改善此类疾病以及其他血管性血友病因子系统异常疾病的预后和管理方法至关重要。
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