School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Arch Gerontol Geriatr. 2010 Jul-Aug;51(1):e16-8. doi: 10.1016/j.archger.2009.07.001. Epub 2009 Aug 8.
DHEA is secreted by the adrenal cortex and is also a neurosteroid. Its sulfate (DHEAS) is the most abundant steroid in circulation. The levels of both are seen to decline in concentration with age. Evidence is available for altered levels of DHEA and DHEAS in AD but is limited to relatively few studies assessing small cohorts. This study assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72). Plasma DHEA concentrations were significantly lower in AD patients compared to control (4.24+/-0.4 ng/ml for AD; 3.38+/-0.3 ng/ml for control, p=0.027, Mann-Whitney 1-tailed) and DHEA levels were significantly correlated to DHEAS levels in both control and AD conditions (Spearman's rho correlation coefficient=0.635 in controls and 0.467 in AD, p<or=0.01). This study highlighted a measurable difference in DHEA and DHEAS concentrations in plasma from a large cohort of patients suffering from AD when compared to age-matched controls.
脱氢表雄酮（DHEA）由肾上腺皮质分泌，也是一种神经甾体。其硫酸盐（DHEAS）是循环中含量最丰富的甾体。随着年龄的增长，两者的浓度都呈下降趋势。有证据表明 AD 患者的 DHEA 和 DHEAS 水平发生了改变，但仅限于少数评估小队列的研究。本研究评估了 AD 患者（n=72）和年龄匹配对照者（n=72）的血浆 DHEA 和 DHEAS 水平。与对照组相比，AD 患者的血浆 DHEA 浓度明显降低（AD 患者为 4.24+/-0.4ng/ml；对照组为 3.38+/-0.3ng/ml，p=0.027，Mann-Whitney 单侧检验），且 DHEA 水平与对照组和 AD 患者的 DHEAS 水平均呈显著相关性（对照组的 Spearman 相关系数为 0.635，AD 患者为 0.467，p<or=0.01）。这项研究强调了与年龄匹配的对照者相比，来自大量 AD 患者的血浆中 DHEA 和 DHEAS 浓度存在可测量的差异。
