Sansonetti Philippe J, Medzhitov Ruslan
Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, 75724 Paris Cedex 15, France; Microbiologie et Maladies Infectieuses, Collège de France, 75231 Paris Cedex 05, France.
Cell. 2009 Aug 7;138(3):416-20. doi: 10.1016/j.cell.2009.07.024.
Research on microbe-host interactions focuses principally on pathogens, yet our immune system must deal with the huge number of beneficial commensal bacteria in our gut. It is becoming clear that the host immune system must reach a delicate balance between destroying dangerous bacterial pathogens while preserving the beneficial gut microbiota.
对微生物与宿主相互作用的研究主要集中在病原体上,然而我们的免疫系统必须应对肠道中大量有益的共生细菌。越来越明显的是,宿主免疫系统必须在消灭危险的细菌病原体和保护有益的肠道微生物群之间达到微妙的平衡。