微小RNA与平行的干细胞生命历程

MicroRNAs and parallel stem cell lives.

作者信息

Dirks Peter B

机构信息

Hospital for Sick Children, University of Toronto, Toronto M5G1X8, Canada.

出版信息

Cell. 2009 Aug 7;138(3):423-4. doi: 10.1016/j.cell.2009.07.025.

DOI:10.1016/j.cell.2009.07.025

PMID:19665962

Abstract

A new study by Shimono et al. (2009) demonstrates that certain microRNAs that regulate the self-renewal factor BMI1 are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-initiating cells. These findings have important implications for the regulation of self-renewal and differentiation by microRNAs and suggest new ways of targeting cancer stem cells.

摘要

下野等人（2009年）的一项新研究表明，在纯化的正常乳腺上皮干细胞和乳腺肿瘤起始细胞群体中，某些调控自我更新因子BMI1的微小RNA表达下调。这些发现对于微小RNA对自我更新和分化的调控具有重要意义，并提示了靶向癌症干细胞的新方法。