Costall B, Domeney A M, Naylor R J
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, U.K.
Neuroreport. 1990 Sep;1(1):77-80. doi: 10.1097/00001756-199009000-00021.
The 5-HT3 receptor antagonists, ICS205-930, granisetron and zacopride, at low doses, inhibited the hyperactivity caused by a 13 day mesolimbic dopamine infusion in the rat. The antagonism decreased with the use of higher doses of the 5-HT3 receptor antagonists. The ability of low doses of the 5-HT3 receptor antagonists to inhibit dopamine-induced behavioural changes is similar to the inhibitory profile of known antipsychotic agents. It is suggested that 5-HT3 receptor antagonists may represent a new class of atypical antipsychotic agents.
5-羟色胺3（5-HT3）受体拮抗剂ICS205-930、格拉司琼和扎考必利在低剂量时，可抑制大鼠中脑边缘多巴胺13天输注所引起的多动。随着5-HT3受体拮抗剂剂量的增加，这种拮抗作用减弱。低剂量的5-HT3受体拮抗剂抑制多巴胺诱导的行为变化的能力，与已知抗精神病药物的抑制特征相似。有人提出，5-HT3受体拮抗剂可能代表一类新型非典型抗精神病药物。
