Barnes N M, Costall B, Naylor R J, Williams T J, Wischik C M
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire.
Neuroreport. 1990 Nov-Dec;1(3-4):253-4. doi: 10.1097/00001756-199011000-00021.
The present studies investigate the possible difference in 5-HT3 receptor recognition site density in amygdaloid and hippocampal homogenates from patients with Alzheimer's disease compared with age-matched controls. The 5-HT3 receptor recognition site radioligand [3H]-(S)-zacopride identified a comparable density of specific sites (defined by granisetron 10.0 microM) in tissues obtained from patients with Alzheimer's disease as compared to age-matched controls (amygdala, Bmax 41 +/- 4 and 43 +/- 9; hippocampus, Bmax 59 +/- 9 and 51 +/- 9 fmol mg-3 protein; tissue from Alzheimer's disease patients and age-matched controls, respectively, mean +/- s.e.m., n = 7-8). These results suggest that the density of 5-HT3 receptor recognition sites labelled by [3H]-(S)-zacopride are not altered in the amygdala and hippocampus of patients with Alzheimer's disease.
本研究调查了与年龄匹配的对照组相比，阿尔茨海默病患者杏仁核和海马匀浆中5-羟色胺3（5-HT3）受体识别位点密度的可能差异。5-HT3受体识别位点放射性配体[3H]-(S)-扎考必利在阿尔茨海默病患者组织中识别出的特定位点密度（由10.0微摩尔的格拉司琼定义）与年龄匹配的对照组相当（杏仁核，最大结合量Bmax为41±4和43±9；海马，Bmax为59±9和51±9飞摩尔/毫克-3蛋白质；分别来自阿尔茨海默病患者和年龄匹配对照组的组织，平均值±标准误，n = 7 - 8）。这些结果表明，[3H]-(S)-扎考必利标记的5-HT3受体识别位点密度在阿尔茨海默病患者的杏仁核和海马中未发生改变。
