Liu H Q, Dun N J
Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153.
Zhongguo Yao Li Xue Bao. 1990 Sep;11(5):415-8.
Effects of verapamil (Ver) on the synaptic transmission of isolated superior cervical ganglia (SCG) were investigated by means of intracellular recording techniques. In the neurons of SCG of rabbits and guinea pigs, Ver (100-400 mumol/L) depressed both the synaptic responses (f-EPSPs and/or evoked action potentials) elicited by orthodromic stimulation and the acetylcholine (ACh) potentials induced by pressure ejection of ACh. 4-Aminopyridine (4-AP, 100 mumol/L) and BaCl2 (5 mmol/L) facilitated the f-EPSPs inhibited by Ver, but had no notable effect on the ACh potentials depressed by Ver. Ver suppressed the ACh potentials enhanced by pyridostigmine (1 mumol/L). The potentiating effect of soman (1 mumol/L) on the ACh potentials was prevented by Ver. It is suggested that Ver can block the synaptic transmission of mammalian SCG by both the pre- and postganglionic mechanisms.
采用细胞内记录技术研究了维拉帕米（Ver）对离体颈上神经节（SCG）突触传递的影响。在兔和豚鼠的SCG神经元中，Ver（100 - 400 μmol/L）可抑制由顺向刺激诱发的突触反应（f - EPSP和/或诱发动作电位）以及由乙酰胆碱（ACh）压力喷射诱导的ACh电位。4 - 氨基吡啶（4 - AP，100 μmol/L）和BaCl₂（5 mmol/L）可增强被Ver抑制的f - EPSP，但对被Ver抑制的ACh电位无明显影响。Ver可抑制由新斯的明（1 μmol/L）增强的ACh电位。Ver可阻止梭曼（1 μmol/L）对ACh电位的增强作用。提示Ver可通过节前和节后机制阻断哺乳动物SCG的突触传递。
