Wariishi Seiichiro, Yamashita Koichi, Nishimori Hideaki, Fukutomi Takashi, Yamamoto Masaki, Radhakrishnan Geethalakshmi, Sasaguri Shiro
Department of Surgery II, Kochi University, Kohasu, Nankoku, Kochi, Japan.
Interact Cardiovasc Thorac Surg. 2009 Nov;9(5):811-3. doi: 10.1510/icvts.2009.212837. Epub 2009 Aug 10.
The purpose of this study was to investigate the efficacy of landiolol hydrochloride, a short-acting beta(1) blocker, by initiating its administration at a low dose (5 microg kg(-1) min(-1)) in patients with postoperative supraventricular arrhythmia. The efficacy of landiolol was evaluated in 38 patients who, after developing postoperative atrial flutter or fibrillation, with sinus tachycardia and two patients who had a history of paroxysmal atrial fibrillation with frequent atrial extrasystole. The heart rate and blood pressure before and 2 h after the administration of landiolol were compared. A return to the sinus rhythm from supraventricular arrhythmia was noted in 89%. The heart rate was reduced from 137+/-26 bpm (before landiolol administration) to 93+/-18 bpm (2 h after the start of the medication, P<0.01). As an agent to correct an arrhythmic condition, landiolol successfully raised the systolic blood pressure from 108+/-24 mmHg (before medication) to 120+/-19 mmHg (2 h after the medication was started, P<0.05). Continuous intravenous infusion of landiolol at a low dose was found to be effective for postoperative supraventricular arrhythmia.
本研究旨在探讨短效β1受体阻滞剂盐酸兰地洛尔在低剂量（5微克·千克-1·分钟-1）起始给药时对术后室上性心律失常患者的疗效。对38例术后发生心房扑动或颤动伴窦性心动过速的患者以及2例有阵发性心房颤动伴频发房性期前收缩病史的患者评估了兰地洛尔的疗效。比较了给予兰地洛尔前后的心率和血压。89%的患者从室上性心律失常恢复为窦性心律。心率从（给药前）137±26次/分钟降至（用药开始2小时后）93±18次/分钟（P<0.01）。作为纠正心律失常状态的药物，兰地洛尔成功地将收缩压从（用药前）108±24毫米汞柱提高到（用药开始2小时后）120±19毫米汞柱（P<0.05）。发现低剂量持续静脉输注兰地洛尔对术后室上性心律失常有效。
