Wadden T A
Weight and Eating Disorders Program, Department of Psychiatry, University of Pennsylvania, 3600 Market Street, Philadelphia, PA 19104, USA.
Postgrad Med. 2001 Jun;109(6 Suppl):29-33. doi: 10.3810/pgm.06.2001.suppl14.76.
A variety of treatments--behavior-modification programs, reduced-calorie diets, and pharmacotherapy--are available to treat obesity and can be effective in producing the 5% to 10% weight loss now recommended as a primary goal of therapy. The mechanisms of action of medication and behavior modification are different and complementary. Behavior therapy helps obese individuals to adopt a diet reduced in calories and fat and to increase daily physical activity; pharmacotherapy assists by modifying internal cues that control eating. Recent clinical studies indicate that combining these approaches is likely to be the most effective treatment for obese patients. Regardless of the approach selected, long-term care is required to achieve and maintain weight loss.
有多种治疗方法——行为矫正计划、低热量饮食和药物治疗——可用于治疗肥胖症，并且在实现目前推荐作为治疗主要目标的减轻5%至10%体重方面可能有效。药物治疗和行为矫正的作用机制不同且相辅相成。行为疗法帮助肥胖个体采用低热量和低脂肪饮食，并增加日常身体活动；药物治疗则通过改变控制饮食的内在信号来提供辅助。最近的临床研究表明，将这些方法结合起来可能是治疗肥胖患者最有效的方法。无论选择哪种方法，都需要长期护理来实现并维持体重减轻。
