哮喘中小气道炎症的病理生理学。
The pathophysiology of small airway inflammation in asthma.
作者信息
Casale Thomas B
机构信息
Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA.
出版信息
Postgrad Med. 2003 Feb;113(2 Suppl):7-12. doi: 10.3810/pgm.02.2003.suppl25.131.
Histologic and imaging studies show that asthmatic inflammation occurs in small airways of the peripheral lung, even in patients with mild disease. Small airway inflammation leads to obstruction that can be detected as peripheral resistance, air trapping, and eosinophil infiltration and is manifested clinically as nocturnal asthma and frequent exacerbations. Inflammatory activity in the distal lung of patients may actually exceed that of the large airways. Anatomic changes in small airways are prominent in cases of fatal asthma.
组织学和影像学研究表明，即使是轻症患者，哮喘炎症也发生在肺外周的小气道。小气道炎症会导致阻塞，可表现为外周阻力增加、气体潴留和嗜酸性粒细胞浸润，临床上表现为夜间哮喘和频繁发作。患者远端肺的炎症活动实际上可能超过大气道。在致死性哮喘病例中，小气道的解剖学改变很显著。
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