de Chaffoy de Courcelles D
Department of Biochemistry II, Janssen Research Foundation, Beerse, Belgium.
Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):401-13. doi: 10.1097/00001721-199010000-00008.
Protein kinase C is a key enzyme in signal transduction systems that involve the breakdown of phospholipids. In the platelet, protein kinase C plays an important role in the induction of the aggregatory and secretory responses as well as in preventing a continuous activation of the platelet excitatory signal transducing system. Furthermore, elevation of platelet cAMP that leads to inhibition of platelet activation appears to interact with the excitatory pathway at the level of protein kinase C. A pivotal role for protein kinase C in platelet activation is proposed.
蛋白激酶C是信号转导系统中的关键酶，该系统涉及磷脂的分解。在血小板中，蛋白激酶C在诱导聚集和分泌反应以及防止血小板兴奋性信号转导系统持续激活方面发挥重要作用。此外，导致血小板激活受抑制的血小板cAMP升高似乎在蛋白激酶C水平与兴奋性途径相互作用。有人提出蛋白激酶C在血小板激活中起关键作用。
