Toronto Congenital Cardiac Centre for Adults, University Health Network/Toronto General Hospital, Canada.
Curr Opin Cardiol. 2009 Nov;24(6):509-15. doi: 10.1097/HCO.0b013e328330cc22.
Coarctation of the aorta is the discrete narrowing of the proximal descending aorta and is the sixth most common lesion in congenital heart disease. Repair of the coarctation can relieve the obstruction, but recurrent coarctation and future aneurysm formation can occur, and a heightened risk of vascular disease is present. This review focuses on advances in the management of native and previously treated coarctation and provides insights into future vascular risk.
Coarctation of the aorta is associated with other left heart obstructive lesions, and advances in the genetic basis of these conditions have been made. Recurrent coarctation and aneurysm formation are common after surgical and endovascular repair of coarctation of the aorta. Endovascular treatment is an acceptable alternative to surgical repair of native and recurrent coarctation. Covered stents and stent grafts can be used to treat arch complications with a low risk of complications. In spite of repair of the obstruction, hypertension persists and appears to be multifactorial due to a variety of factors, including endothelial dysfunction, aortic stiffness, altered arch morphology and increased ventricular stiffness.
People with previously repaired coarctation of the aorta require long-term surveillance for local complications with aortic imaging and surveillance and management of hypertension to prevent vascular disease.
主动脉缩窄是近端降主动脉的离散性狭窄,是先天性心脏病中第六种最常见的病变。修复缩窄可以缓解梗阻,但可能会发生复发性缩窄和未来的动脉瘤形成,并且存在血管疾病的风险增加。本综述重点介绍了对原发性和既往治疗的主动脉缩窄的管理进展,并提供了对未来血管风险的见解。
主动脉缩窄与其他左心阻塞性病变有关,这些病变的遗传基础方面取得了进展。主动脉缩窄的外科和血管内修复后,复发性缩窄和动脉瘤形成很常见。血管内治疗是治疗原发性和复发性主动脉缩窄的一种可接受的替代手术修复方法。覆膜支架和支架移植物可用于治疗弓部并发症,并发症风险低。尽管梗阻得到修复,但高血压仍然存在,由于多种因素,包括内皮功能障碍、主动脉僵硬、弓部形态改变和心室僵硬增加,似乎是多因素的。
既往接受过主动脉缩窄修复的患者需要长期监测主动脉成像,以预防局部并发症,并监测和管理高血压,以预防血管疾病。